Developing a First-in-Class Therapy for Invasive Group A Streptococcal Infections

Targeting a severe and growing medical problem.

Aventera is developing a first-in-class precision immunotherapy against invasive Group A Streptococcal disease. Clinical trials are planned for 2028.

Pipeline //

Advancing toward 
clinical development

Aventera’s lead candidate is currently in the preclinical stage, advancing along a clear trajectory toward first-in-human (FIH) studies in 2028.

Project
AV01
Discovery
Completed
Early preclinical
Ongoing
Late preclinical
Phase 1
Phase 2

Science //

A growing and life-threatening problem

Severe invasive Group A Streptococcal (iGAS) infections are surging, and standard-of-care treatments are proving inadequate. Current protocols rely heavily on antibiotics; however, escalating antimicrobial resistance and stagnant clinical outcomes underscore the critical limitations of existing approaches.

0

Mortality In severe invasive infections, despite current standard of care.

0

U.S. Cases Annual incidence with a growing burden on healthcare systems.

Blockbuster Market Potential:

Independent market research confirms that addressing this rare, high-mortality indication enables a premium pricing strategy for a new clinical asset.

Rapid verification

Routine Strep-A rapid tests provide reliable, immediate identification of the bacterial target.

Aventera Antibodies //

A rational solution to a critical problem

Aventera is bringing precision medicine to the fight against Invasive Group A Streptococcal (iGAS) infections. We have isolated potent protective antibodies from individuals who have successfully overcome severe streptococcal infections.

  • Broad Strain Coverage & Potent Efficacy: By utilizing careful epitope selection, we have identified a lead candidate that offers strong immune-mediated killing of GAS alongside broad strain coverage.
  • Advanced Engineering: Through proprietary precision engineering, we have further enhanced this natural antibody into a highly effective therapeutic.
  • The Therapeutic Window: In iGAS, early intervention is vital. Coupled with a rapid diagnostic test, our therapy enables clinicians to intervene during a critical moment—eliminating the bacteria before it triggers severe, life-threatening disease thereby reducing mortality.
Our team //

Meet our visionaries

Aventera combines deep scientific expertise with proven experience in drug development, manufacturing, and business development.

Management Team

Arman Izadi

CEO, Founder

Caitriona Grönberg

Head of Preclinical

Lena Wester Rosenlöf

Head of CMC

Board of Directors

Göran Forsberg

Chairman of Board of Directors

Eddie Thordarson

Board of Directors

Fredrik Joabsson

Board of Directors

Liselotte Larsson

Board of Directors

Scientific Advisory Board

Pontus Nordenfelt

Chairman of the Scientific Advisory Board, Board of Directors, Founder

Victor Nizet

Scientific Advisory Board

Michael Dustin

Scientific Advisory Board

Adam Linder

Scientific Advisory Board

Research and publications //

April 27, 2023

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances..

Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody..

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